We are conducting systematic reviews and meta-analyses of the scientific literature related to CCSVI and MS, with updates about three times a year. This means that we regularly scan the scientific literature about CCSVI and MS; identify all of the studies that meet a certain scientific standard, and abstract the results from those studies. If studies used similar methods, we statistically combine the results using a technique called meta-analysis.
- This study was published in the Canadian Medical Association Journal (CMAJ) in early October, 2011: “Association between chronic cerebrospinal venous insufficiency and multiple sclerosis: a meta-analysis”. It is a meta-analysis of all peer-reviewed studies that compared the frequency of chronic cerebrospinal venous insufficiency (CCSVI) in patients with and without multiple sclerosis (MS) using ultrasonography that were published before June, 2011.
- This is a lay summary of the CMAJ paper.
- This is a commentary about our CMAJ article written by Dr. Robert Fox, a neurologist from the Cleveland Clinic who specializes in MS.
- Our December 2012 update for the CIHR Expert Panel, which includes literature published between March, 2012 and September, 2012 is available here. The cover letter to Dr. Alain Beaudet, outlining the findings, can be found here.
- Our June 2012 update for the CIHR Expert Panel, which includes literature published between September, 2011 and March, 2012 is available here. The cover letter to Dr. Alain Beaudet, outlining the findings, can be found here.
- November 21, 2011 – our second report to the CIHR, which includes studies that were published between July and September 2011. The cover letter to Dr. Alain Beaudet, outlining the specific updates, can be found here.
- This is a lay summary of our second report to the CIHR.
- The reports of our systematic reviews are being shared with the CIHR Scientific Expert Working Group. Our first report was presented to the Working Group on June 28, 2011. In addition to the CMAJ paper, it summarizes the literature about the use of magnetic resonance venography and contrast venography to assess cerebral veins, as well as what is known about the side-effects of treating CCSVI. The full report is available on the St. Michael’s Hospital website.
- You can also view a video lecture about our findings on YouTube.